MYC and neoplasm: Using similar approaches as VEL identification, we identified the variant super-enhancers loci (VSEL) in tumor tissues, including 334 gain VSELs and 121 lost VSELs, among which several well-known oncogenic targets were identified, such as MYC, VEGFA, and LIF (Fig. 4A, Supplementary Fig. S8A and B, Supplementary Data 6&7).