Interestingly, many genes related with epigenetic regulation of enhancer activity are frequently mutated in cancer, such as lysine methyltransferase 2 C/D (KMT2C/D, also named as MLL3/4), E1A binding protein p300 (EP300), CREB binding protein (CEBBP), lysine demethylase 6 A (KDM6A, also named as UTX) and lysine demethylase 5 C (KDM5C)12,16–20. The gene discussed is KDM5C; the disease is cancer.