We performed in silico prediction of CD8 + T cell epitopes within the SARS-CoV-2 S1 domain restricted by the HLA class I alleles of the immunosuppressed COVID-19 patient (HLA-A*02:01, HLA-A*03:01, HLA-B*51:01, HLA-B*56:01). The gene discussed is HLA-B; the disease is COVID-19.