Additionally, genes that were positively-regulated by KLF5 in R1-AD1 cells were positively enriched in gene expression data comparing clinical NEPC vs. CRPC tissues (Supplementary Fig. 10c, d) as well as gene expression data comparing NEPC vs. primary prostate cancer tissues (Supplementary Fig. 10e, f). The gene discussed is KLF5; the disease is prostate cancer.