As an atypical activated domain, pathogenic enhancer bound by BRD4-NUT with hyper H3K27 acetylation signature in NUT midline carcinoma was reported to form “megadomains” raging from 100 kb to 2 Mb (54), although the presence of natural enhancers like this is still unknown. The gene discussed is BRD4; the disease is nut midline carcinoma.