GAB2 and Hepatic steatosis: Combine this finding with GAB2 being regarded as a candidate gene regulating hepatic steatosis and steatohepatitis [38, 39], we decided to firstly evaluate if GAB2 belongs to genes that showing decreased DNA methylation in the promoter region coupled with increased mRNA expression in liver and adipose of NASH after LFD or ELFD intervention; animal experiment followed by human trial was thus carried on.