GAB2 and metabolic dysfunction-associated steatohepatitis: Nevertheless, only methylation of CpG_5 and CpG_18.19 of GAB2 was associated with ALT and AST in liver, which might result from the tissue specific changes between liver and adipose in NASH after LFD and ELFD intervention, as NASH and these lifestyle interventions can make it difficult to not only identify the pathological or adaptive role of DNA methylation events but also to recognize the primary benefits that triggers secondary or systemic changes of these stimulation.