Considering that CpG sites within the promoter region of human GAB2 gene were reported to be hypomethylated in the blood of NAFLD patients in response to LCD and ELCD, and GAB2 deletion prevented hepatic steatosis induced by HFD and steatohepatitis induced by MCD diet in mice [38], in this study, GAB2 in the LFD vs. MCD or ELFD vs. MCD comparison was selected to examine its DNA methylation and gene expression in liver and adipose of NASH mice after LFD or ELFD intervention. Here, GAB2 is linked to metabolic dysfunction-associated steatotic liver disease.