Yaskolka et al. [19] suggested that differential DNA methylation of alpha-2-macroglobulin pseudogene 1 (A2MP1) and calcium release activated channel regulator 2 (ACRACR2A) in blood could be the epigenetic markers for intrahepatic fat in NAFLD patients after diet and physical activity intervention, respectively. Yoon et al. [18] reported that DNA methylation of caspase 1 (CASP1) and NADH dehydrogenase 1 beta subcomplex 9 (NDUFB9) were downregulated and upregulated in liver of obese mice respectively, in response to high fat diet (HFD) compared with the control diet. The gene discussed is CASP1; the disease is metabolic dysfunction-associated steatotic liver disease.