In a mouse model involving conditional deletion of Pten in 40% of fetal liver HSCs by the expression of VE-cadherin-Cre, Pten deficiency leads to a t(14;15) chromosomal translocation involving the Tcra and c-myc loci and subsequent T-ALL formation similar to a t(8;14) associated with a subset of human T-ALL. Here, MYC is linked to acute lymphoblastic leukemia.