The different oncogenic routes followed by transformation of early-immature cells versus cells of more advanced stages of differentiation may explain why p53 loss of function is associated also, although not as frequently as in common adult cancers to acute leukemias that, interestingly, contain a different spectrum of p53 mutations (for instance, nonmutational wtp53 inactivation predominates in AML (acute myeloid leukemia) [25]. The gene discussed is TP53; the disease is cancer.