In addition, constitutive expression of c-myc can be more oncogenic when expressed in a chronologically inappropriate developmental stage as demonstrated by c-myc expression under the control of Ig enhancers in Burkitt lymphoma or the t(14;15) chromosomal translocation involving the T cell receptor α (Tcra) and c-myc loci in T-ALL induced by Pten deficiency which is similar to a t(8;14) associated with a subset of human T-ALL [45] to be discussed later). Here, PTEN is linked to acute lymphoblastic leukemia.