CD34 and leukemia: However, the leukemia initiating cells (LICs) which in this model share the immunophenotype of GMPs (Lineagelow, c-Kithigh, FcγRII/III+, CD34+) exhibited, contrary to non-neoplastic GMPs, markedly reduced pAktSer473 and pAktThr308 in response to stimulation with SCF.