NOTCH1 and leukemia: Some conclusions can be drawn from these findings:It is not expected that HSC should be the direct ancestor of the LIC (leukemia initiating cell) that arises after a chromosomal translocation occurring during TCR recombination but, nothing a priory, precludes that HSC would be the cell of origin of Notch1/c-myc induced leukemia in Pten deficiency.