RUNX1T1 and acute myeloid leukemia: The ability of all these translocation products (AML-ETO, PML-RARα and PLZF-RARα) to activate Wnt signaling through induction of plakoglobin (γ-catenin) which blocks β-catenin degradation and activates TCF, LEF and their target gene c-myc contributes to enhanced cell proliferation and preservation of immature features [87].