The ability of all these translocation products (AML-ETO, PML-RARα and PLZF-RARα) to activate Wnt signaling through induction of plakoglobin (γ-catenin) which blocks β-catenin degradation and activates TCF, LEF and their target gene c-myc contributes to enhanced cell proliferation and preservation of immature features [87]. The gene discussed is PML; the disease is acute myeloid leukemia.