In the hematopoietic system additional factors such as the specific role of Gata 2 in myeloid development and cooperating mutations such as mutation of ASXL1 gene may play an additional role especially in myeloid malignancies [119] As expected from their respective roles in hematopoiesis, Gata2 expression precedes Gata1 expression. The gene discussed is GATA2; the disease is myeloid neoplasm.