However, by separating the leukemic population from each genotype into an HSC-containing fraction (Sca-1+), a myeloid-progenitor fraction (Sca-1−, Mac-1lo/+ c-Kit+) and a differentiated fraction (Sca-1− Mac-1hi c-Kitlo/−, it was shown that only the myeloid-progenitor fraction gave rise to leukemia. This evidence concerns the gene KIT and leukemia.