TP53 and acute leukemia: Telomerase displays other functions relevant for tumorigenesis like protection from apoptosis [41, 42], (it may antagonize apoptosis induced by p53), activation of quiescent stem cells and induction of HSC mobilization, a property shared with p53 loss of function mutations and c-myc [26, 43] as well as protection of genetic stability which may help to explain the diploid karyotype of many acute leukemias [42].