To investigate the association between rs17268364 in the CTLA4-ICOS intergenic region and SLE susceptibility, we validated the genetic association results in the Henan cohort (2053 cases and 1845 controls from Central of China) and Beijing cohort (2303 SLE patients and 19,262 healthy controls from North of China). This evidence concerns the gene CTLA4 and systemic lupus erythematosus.