For example, In the Eμ-Myc transgenic mouse model of aggressive B-cell lymphoma, BPTF allele is sufficient to delay lymphomagenesis, which display decreased c-MYC levels and pathway activity [104], suggesting that interruption of the c-Myc-BPTF-NURF complex interaction is a potential strategy for the treatment of c-Myc driven tumors. This evidence concerns the gene BPTF and B-cell non-Hodgkin lymphoma.