Through the TCGA database analysis, RBBP4/7 and BPTF is simultaneously overexpressed in ESCA, LIHC, STAD etc. and downregulated in KIRC, KICH, kidney renal papillary cell carcinoma (KIRP) and prostate adenocarcinoma (PRAD) (Fig. 2A). The gene discussed is BPTF; the disease is prostate adenocarcinoma.