SOX4 and neoplasm: For example, in gastric tumor cells, the circ-DONSON recruits the SMARCA1-NURF complex to the SOX4 promoter by directly interacting with SMARCA1, which facilitates tumor cell development via enrichment of the active markers H3K27ac and H3K4me3 on the promoter and activation of SOX4 transcription [115] (Fig. 6A).