According to the TCGA database, BAZ2B is down-regulated in a variety of tumors, such as KICH, lung squamous cell carcinoma (LUSC), BRCA, etc. (Fig. 2A) Moreover, BAZ2B possess highly frequency mutations and abnormal copy number in some tumors, such as melanoma, bladder cancer, COAD, HCC, etc. (Table 2 and Table 3) However, its pathogenic mechanisms still remain unclear, and need to be further explored. The gene discussed is BAZ2B; the disease is melanoma.