Through TCGA database analysis, we found that BAZ1A, CHRAC1 and POLE3 are simultaneously up-regulated in a variety of tumors, such as esophageal carcinoma (ESCA), liver hepatocellular carcinoma (LIHC), STAD, breast invasive carcinoma (BRCA), etc. (Fig. 2A). Here, CHRAC1 is linked to invasive breast carcinoma.