In lung cancer, the region between − 428 and − 377 of the E-cadherin promoter contains a binding site for RBBP7, where RBBP7 functions as a transcriptional activator of the E-cadherin gene by binding to its promoter region, thereby repressing EMT progression [106] (Fig. 5B). The gene discussed is RBBP7; the disease is lung carcinoma.