Moreover, RBBP4 or RBBP7 and BPTF possess high frequency of abnormal copy number in angiosarcoma, breast cancer, pancreatic cancer, prostate cancer and gastric cancer (Table 3), and are mutated in colorectal adenocarcinoma, lymphoma, melanoma, etc. (Table 2). Here, RBBP7 is linked to Familial prostate cancer.