HDAC2 and breast cancer: Additionally, in breast cancer, the transcription factor TWIST recruits an RBBP7/4-MTA2/Mi-2/HDAC1/HDAC2 complex to the proximal regions of the E-cadherin promoter for transcriptional repression via an interaction with RBBP7, which promotes breast cancer cell invasion and metastasis [108] (Fig. 5D).