Notably, MSCs have been shown to inhibit the anti-tumor immune response, including innate and adaptive immune responses, by secreting a variety of soluble factors and mediators (such as prostaglandin E2 (PGE2), IFNγ, IL-4, indoleamine 2,3-dioxygenase (IDO), TGF-β1, IL-6) and interacting with diverse immune cell types (such as T cell, B cells, macrophages, dendritic cells, NK cells and neutrophils) [37]. The gene discussed is IL6; the disease is neoplasm.