In ovarian cancer, tumor-related MSCs were able to induce resistance to hyperthermic intraperitoneal chemotherapy by activating the CXCL12-CXCR4 axis, and when the CXCL12/CXCR4 interaction was blocked, the cytotoxicity of hyperthermia was restored [91]. This evidence concerns the gene CXCL12 and ovarian carcinoma.