We observed that BM-MSCs showed significant HLA-G1, G1/G5, and G5 expression at 1000 ng/ml, AD, and DP-MSCs showed the highest expression of surface and intracellular HLA-G at 2000 ng/ml whereas soluble HLA-G is highly expressed at 3000 ng/ml. This evidence concerns the gene HLA-G and Alzheimer disease.