CD8A and neoplasm: To state a few are tumor-associated macrophages (TAM) for silencing tumor-infiltrating CD8 + T cells, [18] natural killer (NK)2cells clearing pulmonary metastasis of anaplastic thyroid cancer cells, [19] the pro-metastatic role of neutrophils, [20] and immunosuppressive activity of tumor-derived dendritic cells, [21] revealing the pathway activating a humoral immune response in a melanoma model [22] and contribution of stromal cells in navigating metastasis.