In another murine model of atherosclerosis, either blockage of lymph drainage or inhibition of VEGFR-3-dependent lymphangiogenesis will result in increased CD3+ T cell density in plaque intima and adventitia, and deteriorate atherosclerosis, indicating that lymphangiogenesis is responsible for T cell drainage from the lesion [40]. The gene discussed is FLT4; the disease is atherosclerosis.