Jönsson Jönsson T T Atwal Atwal JK JK Steinberg Steinberg S S A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline Nature Nature 2012 2012 488 488 96 96 99 99 10.1038/nature11283 10.1038/nature11283 22801501 22801501. The gene discussed is APP; the disease is early-onset autosomal dominant Alzheimer disease.