Although the etiology of the disease is fully complex including different types of genomic alteration in some genes, e.g. MC1R, CDKN2A, and CDK4, nonfunctional CDK4 is the cardinal hallmark of the disease cutaneous malignant melanoma-3 (CMM3). The gene discussed is MC1R; the disease is melanoma, cutaneous malignant, susceptibility to, 3.