In recent year, the keywords that still maintain the state of bursting citation included “phosphatidylinositol 3, middle aged, adult, aged, human tissue, major clinical study, male, female, lung adenocarcinoma, gene mutation, ATM protein, APC protein, P53 protein, biomarker”, which are considered as emerging hotspots and future research trends of LKB1. Here, APC is linked to lung adenocarcinoma.