Analyzing the functions of miRNA and TF in previous studies, it was found that the non-coding genes hsa-miR-572 [21], hsa-miR-29a-3p [22], hsa-miR-29b-3p [23], hsa -miR-208a-3p [24], hsa-miR-153-3p [25], hsa-miR-29c-3p [26] may be related to diabetic nephropathy and transcription factors HIF1α [27], KLF4 [28], KLF5 [29], RUNX1 [30], SP1 [31], VDR [32], WT1 [33] may be related to diabetic nephropathy. This evidence concerns the gene KLF5 and diabetic kidney disease.