CadN2 is an underexplored protein in Drosophila and is the best matched ortholog to 17 Cadherins in humans (Larkin et al. 2021), of which three—CDH2 (Vite and Radice 2014; Mayosi et al. 2017; Turkowski et al. 2017), CDH5 (Bouwens et al. 2020), and CDH13 (Teng et al. 2015; Verweij et al. 2017)—play a role in, or correlate with, cardiovascular disease. Here, CDH2 is linked to cardiovascular disorder.