Cadherins, Snail1, and LOXL2 are major components in the endothelial-to-mesenchymal transition (EMT; Cuevas et al. 2014) and EMT is a key modulator of age-related diseases including cancer and cardiovascular disease (Brabletz et al. 2018; Santos et al. 2019; Chen et al. 2020). The gene discussed is LOXL2; the disease is cancer.