WDR35 and fibrosarcoma: Moreover, studies on clathrin-mediated exocytosis demonstrated that depletion of human clathrin heavy or light chains results in increased total fusion events with complete release of membrane cargos from vesicles in fibrosarcoma cells (Jaiswal et al., 2009), the opposite to what is observed in Wdr35 mutants where vesicles stack up adjacent to the ciliary sheath but do not fuse.