VWF and congenital rubella syndrome: To be specific, the serum VWF, Ang‐2,sICAM‐1 and sVCAM‐1 concentrations were higher at the peak of CRS than at the start of CRS, while VWF, Ang‐1, Ang‐2, Ang‐2:Ang‐1 ratio, sE‐selectin and sICAM‐1 concentrations were reduced when CRS stopped, suggesting that the degree of endothelial cell activation was correlated with the development of CRS, which would facilitate the monitoring of patients with CRS.