CRS involves a complex, interconnected network of multiple cytokines and immune cells, in which interferon(IFN)‐γ, interleukin(IL)‐1, IL‐6, IL‐18 and tumour necrosis factor (TNF) are key cytokines, monocytes and macrophages are the main driver cells reported in recent studies.5 This evidence concerns the gene IL6 and congenital rubella syndrome.