Accordingly, we compared the levels of ALT, AST, BUN and Cr with endothelial cell activation markers in patients with CRS, and results showed that the serum Ang‐1, Ang‐2, Ang‐2:Ang‐1 and sICAM‐1 were increased in patients with liver function injury, and the serum VWF, Ang‐1, Ang‐2, sE‐selectin and sICAM‐1 were increased in patients with renal function injury, suggesting that biomarkers of endothelial cell activation might be involved in liver and renal function injury in CRS patients. The gene discussed is GPT; the disease is congenital rubella syndrome.