Multiple progeria mouse models, such as Zmpste24−/−, Ercc1−/−, and aP2‐cre; Ercc1fl/−, have been shown to exhibit reduced fat depots similar to naturally aged WT mice (Karakasilioti et al., 2013; Peinado et al., 2011). This evidence concerns the gene ERCC1 and progeroid syndrome.