PAH exposure during the prenatal time window also was associated with lower methylation of the peroxisome proliferator-activated receptor gamma (Pparγ) promoter and increased mRNA expression of Pparγ, C/EBPα, and Cox-2, which are transcription factors involved in adipocyte differentiation and function [62]. The gene discussed is PPARG; the disease is pulmonary arterial hypertension.