By using the integrated and precise 24-plex cytokine/chemokine panel, our findings demonstrated an increase in ten (IFN-α2, IFN-γ, IL-6, IL-8, IL-10, IL-15, IL-18, IP-10, MCP-1, MIG, and RANTES) and a decrease in one (IL-17A) cytokine/chemokine in all dengue cases compared with healthy subjects. This evidence concerns the gene CXCL8 and dengue disease.