In contrast, based on the results (Table S5 and Figure 4(c)), the cytokine levels showed a decreasing trend that was not statistically significant (IFN-γ, P = 0.06, and RANTES, P = 0.071) in the acute phase of the SDD group (IFN-γ, x®=38.4 pg/mL, and RANTES, x®=6515.1 pg/mL) compared to the MDF group (IFN-γ, x®=110.6 pg/mL, and RANTES, x®=12021.6 pg/mL), indicating an inability of the immune response to defend against the infection, thus promoting the progression to severe infection. The gene discussed is CCL5; the disease is infection.