Our results exhibited that liver NLRP3, caspase-1, caspase-1 (p10), and IL-1β were significantly upregulated in the NAFLD model group mice (Figures 6(a), 6(c), and 6(d)) and which were significantly decreased in Man-treated mice (Figures 6(a), 6(c), and 6(d)). The gene discussed is CASP1; the disease is metabolic dysfunction-associated steatotic liver disease.