As extensively reported, the NLRP3 inflammasome mediates inflammation induced by many noninfectious factors, such as lipid accumulation, oxidative stress from hyperglycemia, and hyperlipidemia [35, 36], and participates in the causing of many diseases, including NAFLD, obesity, diabetes, and cardiovascular diseases [16, 35, 37]. The gene discussed is NLRP3; the disease is obesity due to melanocortin 4 receptor deficiency.