Moreover, activated p53 acts as a suppressor directly suppressing the transcriptional activity of NF-κB, and aberrant inflammation can enhance tumor development when p53 is lost (Kawauchi et al., 2008a, b; Son et al., 2012; Gudkov and Komarova, 2016; Uehara and Tanaka, 2018). The gene discussed is NFKB1; the disease is neoplasm.