Di Minin et al. (2014) reported that mutp53 in cancer cells reprogram NF-κB and JNK activation in response to TNFα through the binding and interfering the tumor suppressor RasGAP Disabled 2 Interacting Protein (DAB2IP) in the cytoplasm. Mutp53 can also interact with NF-κB directly, enhancing RNA polymerase II recruitment in response to chronic TNF signaling which shapes the enhancer landscape and oncogenic gene expression (Rahnamoun et al., 2017). The gene discussed is NFKB1; the disease is cancer.