Since inflammation promotes tumor metastasis and can be triggered by activating the NLRP3 inflammasome via ROS-dependent mitochondrial damage (Hamarsheh and Zeiser, 2020), the silibinin-induced mitochondrial fission inhibits NLRP3 inflammasome activation and migration possibly by an antioxidant mechanism (Hamarsheh and Zeiser, 2020). Here, NLRP3 is linked to neoplasm.