Despite the above, the PGC-1α overexpression decreases cellular invasiveness in prostate and melanoma (Luo et al., 2016a; Torrano et al., 2016), showing that the link between increased PGC-1α expression, mtROS, and metastasis still remains controversial and suggests specific roles in tumorigenesis dependent on cancer type (LaGory et al., 2015; Piskounova et al., 2015; Liu et al., 2017). This evidence concerns the gene PPARGC1A and melanoma.