The PGC1a-driven metabolic adaptations with increased OXPHOS are essential to tumorigenesis, showing a positive influence on metastasis in several cancers, such as breast (Cai et al., 2016; Luo et al., 2016b; Andrzejewski et al., 2017; Pacheco-Velázquez et al., 2018), hepatocellular (Li et al., 2016), colorectal (Yun et al., 2019), endometrial (Chen et al., 2020), prostate (Tennakoon et al., 2014), pancreatic cancers (Sancho et al., 2015), and in some models of melanoma (Vazquez et al., 2013). This evidence concerns the gene PPARGC1A and cancer.