Invasive cancer cells use the transcription coactivator peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PPARGC1A, also known as PGC-1α) to enhance mitochondrial biogenesis and OXPHOS, being an essential event for functional motility and metastasis in breast cancer cells (LeBleu et al., 2014). The gene discussed is PPARGC1A; the disease is breast carcinoma.