BRCA1 and breast cancer: For example, we found that two modules associated with immune response and cell cycle regulation were significantly correlated with clinical traits (tumor M stage and poor prognosis) in BRCA1-MUT BC, but without significant influence in WT BC, suggesting that the modules and associated genes influenced by BRCA1 mutations could regulate and cause dysfunction of the cell cycle and immune response, and thus influence the metastasis and prognosis of BRCA1-MUT BC.