Based on their expression levels in BRCA1-MUT BC relative to normal samples, many TFs were also significantly upregulated in the BRCA1-MUT group, including in the purple module [STAT1 (log2FC = 1.62) and IRF1 (log2FC = 1.10)] and turquoise module [E2F7 (log2FC = 3.16), E2F1 (log2FC = 2.83), FOXM1 (log2FC = 4.13), E2F2 (log2FC = 3.03), and MYBL2 (log2FC = 4.20)], suggesting a positive feedback loop in the regulation of BRCA1-associated carcinogenesis. The gene discussed is BRCA1; the disease is breast cancer.