The turquoise and purple modules in the BRCA1-MUT group and the red, purple, blue, turquoise, black, greenyellow, and brown modules in the BRCA2-MUT group due to their correlations with clinical traits, were identified as clinically significant modules associated with carcinogenesis, progression, and metastasis of BRCA1/2-MUT BC. This evidence concerns the gene BRCA1 and breast cancer.