We extracted two IPS values (IPS-PD-1/PD-L1/PD-L2_pos and IPS-CTLA-4_pos) from the TCIA database to measure the response of ccRCC patients to anti-PD-1/PD-L1 and anti-CTLA4 treatment alternatives. This evidence concerns the gene PDCD1LG2 and nonpapillary renal cell carcinoma.