Our previous research found that E3 ubiquitin ligase WWP1 can stabilize DVL2 by catalyzing K27-linked polyubiquitination, and DVL2 positively correlated with WWP1 hypertrophic heart and mediated the regulation of the CaMKII/HDAC4/MEF2C axis in cardiac hypertrophy by WWP1 (Zhao et al., 2021). The gene discussed is HDAC4; the disease is cardiac hypertrophy.