IGKV3D-20 and neoplasm: Non-small cell lung carcinoma (NSCLC) xenografts in α11 knockout (α11–/–) severe combined immune deficient (SCID) mice was significantly impeded, as compared with wild-type (α11+/+) SCID mice, which showed that collagen cross-linking was associated with stromal α11 expression, and the loss of tumor-stromal α11 expression was related to collagen reorganization and the decrease of stiffness (Navab et al., 2016).