NDST1 and Carcinoma, Lewis Lung: El Ghazal et al. (2016) found that targeting of DC glycan sulfation through mutation in the heparan sulfate biosynthetic enzyme N-deacetylase/N-sulfotransferase-1 (Ndst1) in mice (Ndst1f/f LysMCre+) increased DC maturation and inhibited trafficking of DCs to draining lymph nodes, and Lewis lung carcinoma tumors of Ndst1f/f LysMCre+ mice were reduced in size (El Ghazal et al., 2016).