Meanwhile, studies on genetic predisposition of secondary lymphedema have demonstrated a significant association of VEGFR, RAR-related orphan receptor C (RORC), FOXC2, and interleukin-6 (IL6) genes with secondary lymphedema (Newman et al., 2012; Miaskowski et al., 2013; Leung et al., 2014). This evidence concerns the gene KDR and lymphedema.