FBXL5 and cancer: On the other hand, nuclear FBXL5 protein also functions as a ubiquitin ligase of SNAI1 (Vinas-Castells et al., 2014), which is a key modulator of the EMT and thus involved in multiple kinds of cancers (Moody et al., 2005; Carmichael et al., 2020; Chen R. et al., 2021).