ITGB1 and leukemia: In turn, up-regulating ITGB1 in leukemia cells could enhance the interaction between leukemia cells and MSCs with CAF-like phenotype, and partially reverse the interference of AMD3100 on the interaction between leukemia cells and MSCs with CAF-like phenotype, indicating that targeting ITGB1 may be an effective treatment method to reduce the disease progression and extramedullary infiltration of leukemia cells.