CXCL12 and neoplasm: The specific binding of SDF-1 and CXCR4 form the SDF-1/CXCR4 biological axis, which is a key signal axis that mediates the interaction between tumor cells and stromal cells, and is highly related to cell adhesion, migration and invasion (de Lourdes Perim et al., 2015; Benedicto et al., 2018).