Results revealed that both ITGA5 and ITGB1 were expressed on the membrane of leukemia cells, and the expression levels of ITGA5 and ITGB1 in leukemia cells in the co-culture system of TGF-β conditioned MSCs exhibited a higher trend, after AMD3100 was added into the co-culture system, the expression levels of ITGA5 and ITGB1 in leukemia cells seemed to decrease (Figures 6C,D). Here, TGFB1 is linked to leukemia.