Many studies have exhibited that the activation of MAPK (p38, JNK1/2, and ERK1/2) signaling during pathological stress accelerated the process and development of cardiac hypertrophy and transformation to heart failure (Rose et al., 2010; Yokota and Wang, 2016; Gallo et al., 2019). The gene discussed is MAPK3; the disease is cardiac hypertrophy.