Altered KRAS and TP53 were the most commonly altered genes and demonstrated concordance in three cohorts, with less prevalence in the stroma than in the other two cohorts (71.2% and 61.5% in stroma, 94.0% and 86.0% in tumor, and 90.7% and 69.3% in TCGA) (Figure 1C). Here, TP53 is linked to neoplasm.