ADORA2A and hepatocellular carcinoma: Furthermore, the expressions of ADORA2A-AS1 in immortalized human liver cell THLE-2 and human HCC cells SNU-398, SK-HEP-1, and Hep3B were measured, and the results revealed that ADORA2A-AS1 was lowly expressed in HCC cells compared with that in immortalized liver cell (Figure 1C).