HBV DNA >2,000 IU/ml, ALT >ULN and moderate liver necro-inflammation or fibrosis (F2 minimum) Compensated or decompensatedcirrhosis with detectable HBV DNA HBV DNA >20,000 IU/mland ALT ≥2 x ULN HBeAg positive, high HBV DNAlevel, and age 30 yr Family history of HCC, cirrhosis, extrahepaticmanifestations. This evidence concerns the gene GPT and hepatocellular carcinoma.