A recent study by Sun et al. (2017) has shown that HES1 modulates gene expression related to drug metabolism and EMT, notable overexpression of ABC transporters (ABCC1, ABCC2 and P-gp1) with depressed E-cadherins and elevated N-cadherins in CRC cell lines treated with 5-FU, supporting the crucial role of HES1 in promoting chemoresistance. Here, HES1 is linked to colorectal carcinoma.