PRDM9 and colorectal carcinoma: In addition, the regulatory function of histone methylation in multidrug-resistant CRC is also documented in studies that report the relationship between H3K27me3 level and oxaliplatin-induced apoptosis (Wang et al., 2020b), as well as the cancer-driving nature of histone methyltransferase SETDB1 in CRC resistant to cetuximab (Hou et al., 2020).