In addition to MAPK-based signalling involving RTKs, KRAS-mediated activation of the MAPK signalling pathway in CRC has also been demonstrated to confer resistance to MEK inhibition by instigating STAT1 phosphorylation and the activation of IFN/STAT signalling (Sakahara et al., 2019). This evidence concerns the gene MAP2K7 and colorectal carcinoma.