Shortly after the transmission of the signal to downstream effectors, PIP3 is then metabolised by phosphatase and tensin homolog (PTEN), which is a tumour suppressor that negatively regulates the PI3K signal by removing 3′-phosphate from PIP3 (Danielsen et al., 2015; Fruman et al., 2017). The gene discussed is PIK3CD; the disease is neoplasm.