In multidrug-resistant CRC, Wnt/β-catenin pathway is reprogrammed by overexpression of Dvl protein and non-coding RNAs that interfere with the activities of downstream signalling mediators (Yue et al., 2016; Han et al., 2017; Bian et al., 2017; Zhang et al., 2017b; Jiang et al., 2019). The gene discussed is DVL1; the disease is colorectal carcinoma.