Experimental radiotherapy-induced OM in mice treated with aMSCs by intraperitoneal injections (5 doses of 2.5 million of cultured syngeneic aMSCs) resulted in 72% reduction in OM duration associated with a decreased expression of TNF-α, interferon-γ and IL1-β and an increased expression of IL-10 in the oral mucosa. This evidence concerns the gene TNF and ocular melanoma.