Taken together, these findings indicate that the conserved lysines on DVL-1 proteins are critical regulators of Wnt signaling as well as physiologically relevant, wherein it regulates oncogenic biological functions such as 3D-spheroid formation, transwell migration, cell-cycle phases, proliferation, and xenograft tumor growth in triple-negative breast cancer (Figure 6H). Here, DVL1 is linked to triple-negative breast carcinoma.