Figure 5(a) shows that the proinflammatory TNF-α values were enhanced in WKY rats fed with HT and HF diet and were further aggravated in SHRSP animals. Rats in SHRSP/HT and SHRSP/HF groups exhibited the highest TNF-α concentrations, which were mitigated by 12 weeks of exercise. Our statistical findings prove that diet and physical exercise significantly influenced the TNF-α values (Figure 5(b)). Here, TNF is linked to hydrops fetalis.