By comparing the effects of moxibustion and Ro25-6981 plus moxibustion on NR2B, JNK, Bax, Bcl-2, and caspase-3 in the cerebral ischemic area, we explored the neuroprotective effect of moxibustion on cerebral ischemia/reperfusion (I/R) injury and its possible mechanism. The gene discussed is GRIN2B; the disease is brain ischemia.