BNIP3L can directly target mitochondria by binding to Bcl-2 and promote cancer stemness of HCC by glycolysis metabolism reprogramming [18], whereas TFE3 are involved in PINK1 and Parkin-dependent mitophagy and can promote the proliferation of renal cell carcinoma [19]. The gene discussed is PRKN; the disease is hepatocellular carcinoma.