Here, all relevant details about GJB2 c.109G > A have been displayed, including the basic information (in silico missense prediction, allele frequency in different populations, multiple Sequence Alignment retrieved from HomoloGene, and the disease-related information) and the detailed information from the original 146 articles, including the testing method, ethnic origin, total genetic testing samples, and the positive samples, and all the clinical phenotypes associated with the variation containing mild, moderate, severe to profound sensorineural hearing loss. This evidence concerns the gene GJB2 and sensorineural hearing loss disorder.