Also, due to the key role that TLR4 plays in activating the signaling pathways that lead to the secretion of proinflammatory cytokine, this gene has been suggested as a very attractive therapeutic target for inflammatory diseases, such as sepsis in human and equine (Werners and Bryant, 2012; Kuzmich et al., 2017). The gene discussed is TLR4; the disease is Sepsis.