EIF3A and cancer: The individual subunits of the eIF3 complex (eIF3a, eIF3b, eIF3c, eIF3e, eIF3h, and eIF3i) assume an additional role in regulating the translational initiation of specific mRNAs encoding proteins that promote cell growth and hence interfere in the development of cancer and tumor cells in humans (Dong and Zhang, 2006).