In line with these human data, genetic deletion of ILC2 in mice aggravated K/BxN serum-induced arthritis whereas expansion of ILC2 by IL-25/IL-33 mini-circles or adoptive transfer of ILC2 from wild-type but not IL-4-/-IL-13-/- mice attenuated arthritis (55). This evidence concerns the gene IL13 and arthritic joint disease.