On the basis of preliminary studies indicating the key regulatory function of nuclear factor-κB (NF-κB) in TNF production, cell death, immune infiltration, and hyperkeratosis, NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways have been identified to organize psoriatic skin in a Th17-associated manner (27, 28). Here, NFKB1 is linked to Hyperkeratosis.