Tonsillectomy is proven to be a feasible strategy for Streptococcus-associated psoriasis, owing to a high frequency of cutaneous lymphocyte-associated antigen (CLA) + tonsil T cells that preferentially express IL-23 receptors, and these cells are postulated to be correlated with Th17, Th22, or Th1 polarization. Here, SELPLG is linked to psoriasis.