CD4 and neoplasm: To induce broad CD4/CD8+ anti-tumor responses irrespective of HLA subtypes, the full-length MAGED4B or FJX1 sequences were linked to 3’ Dom sequence and inserted into pcDNA3 plasmid to give rise to pDom-MAGED4B (pDom-M, Figure S2A) and pDom-FJX1 (pDom-F, Figure S2B).