Consistent with the impact of EPAC2 KO on RSV-induced disease and airway obstruction, we also found that the treatment of MAY0132, an EPAC2-specific inhibitor (27), attenuated RSV-induced body weight loss, starting at day two postinfection (p.i.), with a further clinical benefit at day three p.i. On day four p.i., the bodyweight loss showed no difference with that of mice without infection (Figure 1C). This evidence concerns the gene RAPGEF4 and infection.