RAPGEF4 and Airway obstruction: Consistent with the impact of EPAC2 KO on RSV-induced disease and airway obstruction, we also found that the treatment of MAY0132, an EPAC2-specific inhibitor (27), attenuated RSV-induced body weight loss, starting at day two postinfection (p.i.), with a further clinical benefit at day three p.i. On day four p.i., the bodyweight loss showed no difference with that of mice without infection (Figure 1C).