Oncolytic peptides LTX-315/401 (140) and RT53 (141) have been shown to trigger ICD and DAMP release (ATP, HMGB1 and Calreticulin), as well as IFN I secretion, in melanoma and fibrosarcoma models; this was associated with local immune infiltration and tumour regression. This evidence concerns the gene HMGB1 and neoplasm.