In mouse models of fibrosarcoma (MCA205) and lung carcinoma (TC-1), I.T. injections of LTX-315 (142)and LTX-401 (143) in combination with anti-PD-1 or anti-CTLA-4 promoted immune-dependent control of injected and abscopal (non-injected) tumour lesions. The gene discussed is PDCD1; the disease is fibrosarcoma.